Characteristics of Autism Spectrum Disorders (ASD)
Autistic Traits: Life Course and Genetic Structure
This study will determine whether children with complex autism differ from children with essential autism by looking at the physical and mental development of children when compared to family members.
Eligibility requirements:
- children age 4+ diagnosed with ASD and one typically developing full sibling and at least one biological parent that is available to participate
- Time required: Approximately 1-4 hours, depending on amount of prior testing
- Location: Thompson Center, University of Missouri
- Monetary compensation: Yes
- Contact Person: Jill Akers, 573-884-6092, akersji@missouri.edu
- Research study director: Judith Miles, MD, PhD
Range of tasks affected by propranolol in autism and effect of sympathetic reactivity
The purpose of this study is to better understand the range of cognitive effects of propranolol in autism. We will test for effects of propranolol on verbal memory, working memory, spatial memory, attention, mood, and anxiety, and determine whether Galvanic skin response and heart rate variability predicts the degree of cognitive benefit.
Eligibility requirements:
- Individuals age 15-24 diagnosed with ASD
- Time required: 2 visits, 2 hours for each visit
- Location: Thompson Center
- Monetary compensation: Yes
- Contact Person: Jill Akers phone: 573-884-6092 email: akersji@missouri.edu
- Research study director: David Beversdorf, MD
Effects of propranolol on functional connectivity in autism and effect of sympathetic reactivity
The purpose of this study is to better understand the effects of propranolol on cognition (thinking) in those with ASD. Participants will attend 3 sessions at the MU Brain Imaging Center where they will take propranolol, nadolol, or placebo (sugar pill). Then, participants will be placed in an MRI machine where we will measure the effects of the drug on language, memory, problem solving, and connectivity in the brain. Furthermore, we will determine whether Galvanic skin response (i.e. level of skin sweat) and heart rate variability predict the degree of benefit from propranolol.
Eligibility requirements:
Individuals 15-25 years of age diagnosed with ASD
Time required: 3 sessions (3-4 hours each session)
Location: MU Brain Imaging Center
Monetary compensation: Yes
Contact Person: Jill Akers, 573-884-6092, akersji@missouri.edu
Research Study Director: David Beversdorf, MD
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